Traditional histopathology is a powerful tool for disease diagnosis, prognosis and inferring mechanisms and pathways of disease as well as evaluation of the efficacy of therapies.

We aim to use slide-scanning technologies, and adapt available open-access microscopy tools to better annotate and analyze these images. This will enable dissemination and engagement with the wider scientific community.

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Molecular analyses of disease processes in multiple species can be compared with medical / human molecular pathology data.

This includes comparison of ‘omics / high throughput data originating from similar types of analysis in humans and similar animals. This involves use of datasets (DNA sequence & copy number data, expression profiling and proteomics) across different tissues and species.

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Modern imaging techniques capture information at the level of the whole body, organs and tissues and at a cellular level. Our aim is to better integrate imaging datasets from these modalities and to link this to allied datasets such as haematology, chemical pathology, ex-vivo, tissue culture, metadata/health records, complex datasets (genomics, proteomics) and functional data.

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To critically assess the differences and similarities in disease processes between species.

We aim to develop open-source bioinformatics tools for comparative and molecular pathology studies for multispecies histopathology, imaging and ‘omics data sets. The relative strengths of different animal models can be evaluated.

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An improved ability to compare patterns of multi-organ pathology within-animal and between-species has wide application to the study of systemic diseases and to cancer.

A deeper understanding of animal disease models may facilitate the discovery of new biomarkers that are relevant for early disease diagnosis in humans and to identify the most appropriate pre-clinical models to new test therapies.

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We provide opportunities to gain experience in comparative and experimental pathology for undergraduate students and trainee medical & veterinary pathologists through placements within the veterinary pathology residency programmes, Roslin Institute, UoE Research Institutes, and our partners.
Trainees can enter the UoE ECAT and ECAT-V schemes that offer a career path for academic pathology.

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About the Centre

Comparative pathology is the integrative study of human and animal disease biology to gain knowledge by comparing disease mechanisms across species and to use this for the benefit of human and animal health.

Our Research

A wide range of cutting edge technologies are used across the Centre’s research to understand biology and pathological mechanisms of a broad range of diseases.

Development of Pathologists

With accredited facilities and training programmes the Centre is able to offer a large number of training opportunities to existing and new pathologists.